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However, you should always consider your dog's weight when dosing a medication — 500 mg is an appropriate dose for a 33 kg (73. It is also known by brand names such as Cephalexin Keflex, Rilexine, Cefadroxil, Sporidex, Biocef, and Keftab. However, it is always wise to watch out for changes in your dog’s health, behavior and demeanor, which should be reported to your vet promptly. Like all antibiotics, it’s important to take all doses and complete the full course of therapy. So, if you observe any of the conditions with your dog, stop giving them cephalexin immediately. Like other antibiotics, it does not work. However, giving some food together with the drug often reduces these side effects. It is effective against common bone, joint, staph, and deep skin infections. Cephalexin can be given with or without food. Some of the side effects include: Drooling Nausea Vomiting Excessive panting Hyperactivity. 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